An extraordinary opportunity to own one of Gananoque's most recognizable landmark properties in the heart of the renowned 1000 Islands tourism district. Perfectly positioned on a prominent corner just steps from the waterfront, 1000 Islands Cruise docks, theatre, boutique shopping, and dining, 130 Main Street offers exceptional visibility, desirable Commercial/Residential zoning, and no restrictive heritage designation, creating remarkable flexibility for investors, entrepreneurs, or those seeking an elegant live-work lifestyle. Whether envisioned as a boutique inn, bed & breakfast, destination restaurant, wine bar, café, professional office, wellness clinic, gallery, retail boutique, or simply a distinguished private residence, the possibilities are endless. This stately circa-1870 Victorian offers nearly 3,000 sq. ft. of beautifully maintained space featuring soaring 10-foot ceilings, oversized principal rooms, bay windows, and timeless craftsmanship. Upstairs you'll find three spacious bedrooms plus an adaptable attic with future potential. Outside, the classic wrap-around veranda overlooks mature English gardens, while the private fenced backyard, framed by towering trees, offers a peaceful retreat complete with a spacious deck, swings, and inviting entertaining areas. Significant updates include modern electrical and plumbing, steel roof, updated furnace and A/C, flooring, paint, and appliances. Rarely does a property combine iconic architecture, premium zoning, modern infrastructure, and one of Eastern Ontario's most coveted downtown waterfront locations.